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采用修改的Wigger法复制出血性休克,使mAP维持5.33kPa(40mmHg)1h。然后夹闭放血管至90min时,将失血在30min内全部输回,再继续观察2h。于失血后60～80min之间,异搏定组(N=6)和对照组(N=7)3次分别静注异搏定0.15mg/kg和等量生理盐水。结果表明,输血后异搏定组动物的总体耗氧量明显增加,与对照组相比输血后1和2h的P值分别小于0.05和0.01;异搏定动物的mAP和左室收缩和舒张压力变化最大速率(±dp/dt max)维持接近失血前水平,输血后2h与对照组相应值相比有明显统计学差异(P值分别小于0.05和0.01);两组动物的心肌耗氧量虽未出现明显差别(P>0.05),但输血2h异搏定组有改善趋势,对照组继续降低。
Hemorrhagic shock was replicated using the modified Wigger method, maintaining mAP at 5.33 kPa (40 mm Hg) for 1 h. Then clamp the tube to 90min, the blood will be lost within 30min all the back, then continue to observe 2h. Between 60 and 80 min after blood loss, verapamil group (n = 6) and control group (n = 7) were intravenously administered with verapamil 0.15 mg / kg and normal saline for 3 times respectively. The results showed that the total oxygen consumption of verapamil group increased significantly after transfusion, compared with the control group, the P values at 1 and 2 h after transfusion were less than 0.05 and 0.01 respectively. The mAP and left ventricular systolic and diastolic pressure The maximum rate of change (± dp / dt max) remained close to the pre-hemorrhage level. There was a statistically significant difference between the two groups at 2h after transfusion (P <0.05 and 0.01 respectively). Although the myocardial oxygen consumption There was no significant difference (P> 0.05), but the blood transfusion 2-hour verapamil group had an improvement trend, the control group continued to decrease.