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作者观察了４６例慢性阻塞性肺病（ＣＯＰＤ）患者睡眠时呼吸和血氧饱和度（ＳａＯ２）变化情况，并同时与１６名健康人对照，结果发现其中有２２例ＣＯＰＤ合并睡眠呼吸暂停综合征（ＳＡＳ），其中有７５％发现鼻咽部异常，而单纯ＣＯＰＤ者仅发现４０％。单纯ＣＯＰＤ患者睡眠时呼吸暂停发作次数多于对照组（Ｐ＜０．０１），而ＣＯＰＤ伴ＳＡＳ者发作次数和时间均超过ＣＯＰＤ和对照组（Ｐ＜０．０１和Ｐ＜０．０５）。患者同时伴有ＳａＯ２下降，单纯ＣＯＰＤ者睡眠后的最低ＳａＯ２、下降ＳａＯ２均低于对照组（Ｐ＜０．０１），ＣＯＰＤ伴ＳＡＳ者最低ＳａＯ２、下降ＳａＯ２、平均ＳａＯ２亦均低于ＣＯＰＤ组和对照组（Ｐ＜０．０１和Ｐ＜０．０５）。ＣＯＰＤ患者睡眠时易发生呼吸紊乱和ＳａＯ２下降。当患者伴有上气道如鼻咽部的解剖异常，则易合并ＳＡＳ，使呼吸暂停频繁发作，ＳａＯ２明显下降，直接影响ＣＯＰＤ和肺心病的发展变化
The authors observed changes in breathing and blood oxygen saturation (SaO2) in 46 patients with chronic obstructive pulmonary disease (COPD) during sleep and at the same time compared with 16 healthy individuals and found that 22 of them had COPD with sleep apnea syndrome SAS), of which 75% found nasopharyngeal abnormalities, compared with 40% in simple COPD. The number of episodes of apnea during sleep in COPD patients was more than that in control subjects (P <0.01). The number and duration of episodes of COPD and SAS in COPD patients were significantly higher than those in COPD and control subjects (P <0.01 and P <0.05). The patients were accompanied by the decrease of SaO2, the lowest SaO2 and the lower SaO2 after sleep in COPD patients (P <0.01), the lowest SaO2 in COPD patients with SAS, the lower SaO2 and the average SaO2 in COPD patients Control group (P <0.01 and P <0.05). COPD patients sleep prone to respiratory disorders and SaO2 decreased. When patients with upper airways such as the anatomy of the nasopharynx, it is easy to merge SAS, frequent episodes of apnea, SaO2 decreased significantly directly affect the development of COPD and pulmonary heart disease