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目的 观察1,6—二磷酸果糖(FDP)治疗新生儿缺氧缺血性脑病的疗效。 方法 将36例患儿分为治疗组和对照组,治疗组在对照组治疗基础上加用FDP,每次250mg/kg,每日二次,7天为一疗程。 结果 治疗组总有效率94.4％,对照组为66.7％,治疗组明显优于对照组,经统计学处理P<0.05,有显著性差异。结论:早期应用FDP治疗新生儿缺氧缺血性脑病,能够缩短病程,提高存活率,减少病残率,临床上值得推广使用。
Objective To observe the therapeutic effect of fructose-1,6-diphosphate (FDP) on neonatal hypoxic-ischemic encephalopathy. Methods Thirty-six children were divided into treatment group and control group. The treatment group was treated with FDP on the basis of the control group, each time being 250mg / kg twice daily for 7 days. Results The total effective rate was 94.4% in the treatment group and 66.7% in the control group, which was significantly better in the treatment group than in the control group. There was a significant difference after statistical analysis (P <0.05). Conclusion: The early application of FDP in neonatal hypoxic-ischemic encephalopathy can shorten the course of disease, improve the survival rate and reduce the morbidity of disability, so it is clinically worth using.