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目的:探讨血管内皮生长因子(VEGF)和表皮生长因子受体(EGFR)在青年乳腺癌的表达及其与淋巴结转移的关系。方法:选择68例青年乳腺癌患者为观察组,选取同期住院治疗的60例中老年乳腺癌患者为对照组,采用免疫组化方法检测两组VEGF及EGFR的表达情况。结果:观察组患者VEGF和EGFR阳性率分别为61.8%和63.2%,显著高于对照组的41.7%和38.3%,差异有统计学意义(P<0.05);观察组患者TNM分期Ⅲ,Ⅳ期患者VEGF和EGFR阳性率显著高于Ⅰ,Ⅱ期患者(P<0.01);有淋巴结转移者VEGF和EGFR阳性率显著高于无淋巴结转移者(P<0.01)。结论:EGFR和VEGF高表达与青年乳腺癌发生及淋巴结转移相关,可能是其侵袭性强、预后差的原因之一。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) in young patients with breast cancer and its relationship with lymph node metastasis. Methods: Sixty-eight cases of young patients with breast cancer were selected as the observation group. Sixty middle-aged and elderly patients with breast cancer who underwent hospitalization in the same period were selected as the control group. The expression of VEGF and EGFR was detected by immunohistochemistry. Results: The positive rates of VEGF and EGFR in the observation group were 61.8% and 63.2% respectively, which were significantly higher than those in the control group (41.7% and 38.3%, P <0.05). The TNM stage Ⅲ and Ⅳ The positive rate of VEGF and EGFR was significantly higher in patients with stage Ⅰ and Ⅱ (P <0.01). The positive rates of VEGF and EGFR in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.01). Conclusion: The high expression of EGFR and VEGF correlates with the occurrence of breast cancer and lymph node metastasis in young patients, which may be one of the reasons for their strong aggressiveness and poor prognosis.