研究旨在观察(1)特发性和糖尿病性胃轻瘫患者静脉注射和口服红霉素对固体餐胃排空的影响;(2)评估治疗期间症状反应;(3)确定长期治疗的效果和安全性。 方法:14例受试者中(女13例,男1例,平均38岁),特发性胃轻瘫10例,糖尿病性胃轻瘫4例。入选标准包括基础胃排空试验证实有胃轻瘫(研究前30天内曾作固体餐2h时胃滞留>70％),无胃外科史、结缔组织病、神经肌肉或内分泌疾病(除糖尿病外);6月内无胃流出道梗阻或消化性溃疡病;症状评估总积分不得低于15分;胃排空基础试验前48小时或研宄期间,禁用其他促动力剂(胃复安、吗丁啉或西沙必利)、止吐剂、抗抑郁剂或止痛剂。静脉注射试验为受试者进同位素标记混合试验餐时(15分钟内)静脉注射红霉 The purpose of the study was to examine (1) the effects of intravenous and oral erythromycin on solid meal gastric emptying in idiopathic and diabetic gastroparesis patients; (2) assessment of the symptomatic response during treatment; (3) the efficacy of long-term treatment And safety. Methods: Among 14 subjects (13 females, 1 males averaged 38 years old), 10 cases of idiopathic gastroparesis and 4 cases of diabetic gastroparesis. Inclusion criteria included gastroparesis (gastric residual> 70% at 2 h after solid meal at 30 days prior to study), no history of stomach surgery, connective tissue disease, neuromuscular or endocrine disease (except for diabetes) ; Gastroesophageal reflux obstruction or peptic ulcer disease in June; Symptom assessment total score of not less than 15 points; Gastric emptying 48 hours before the basic test or during the study period, disable other promoters (metoclopramide, dobutamine Or cisapride), antiemetics, antidepressants or analgesics. Intravenous injection test for subjects into the isotope labeled mixed test meal (within 15 minutes) intravenous injection of erythrocytes