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目的探讨舍曲林联合坦度螺酮治疗慢性肾功能衰竭患者抑郁状态的临床疗效和不良反应。方法 64例慢性肾功能衰竭患者,随机分为研究组和对照组,各32例。研究组采用舍曲林联合坦度螺酮进行治疗,对照组单用舍曲林进行治疗,治疗6周后对比两组临床疗效。结果研究组显效率为93.75%高于对照组的84.38%,差异有统计学意义(P<0.05)。两组均无严重不良反应发生。结论舍曲林联合坦度螺酮治疗慢性肾功能衰竭患者抑郁状态安全有效,可显著改善患者的生活质量,适合用于慢性肾功能衰竭患者抑郁状态的治疗。
Objective To investigate the clinical efficacy and adverse reactions of sertraline combined with tandospirone in the treatment of patients with chronic renal failure. Methods 64 patients with chronic renal failure were randomly divided into study group and control group, with 32 cases in each group. The study group was treated with sertraline plus tandospirone, while the control group was treated with sertraline alone. The clinical efficacy of the two groups was compared after 6 weeks of treatment. Results The effective rate of the study group was 93.75% higher than that of the control group (84.38%), the difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Sertraline combined with tandospirone is safe and effective in treating depression in patients with chronic renal failure, which can significantly improve the quality of life of patients and is suitable for the treatment of depression in patients with chronic renal failure.