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目的探讨睡眠呼吸暂停低通气综合征(OSAHS)对缺血性脑卒中病情及预后等的影响。方法检测2010年10月至2011年1月中国医科大学附属第一医院收治的18例OSAHS合并缺血性脑卒中患者(A组)及20例缺血性脑卒中患者(B组)血常规、凝血三项、D-二聚体、血脂,并进一步分析上述指标变化与睡眠呼吸暂停严重程度之间的相关性。结果两组患者年龄、性别、体重指数(BMI)、高血压病比例、红细胞计数(RBC)、血红蛋白(Hb)、红细胞比积(MCV)、血小板数目(PLT)、血小板比积(PCT)、血脂之间差异无统计学意义;A组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)低于B组患者,纤维蛋白原(Fg)、D-二聚体高于B组患者。分析A组发现,氧减指数(ODI)与Fg相关系数(r)为0.466,血氧饱和度小于90%时间占总睡眠时间百分比(T90%)与Fg之间呈正相关(r=0.535,P<0.05);D-二聚体与T80%呈正相关(r=0.529,P<0.05),与夜间最低血氧饱和度呈负相关(r=-0.604,P<0.01)。结论OSAHS对缺血性脑卒中患者凝血指标有影响,可促进血液的高凝。
Objective To investigate the effect of sleep apnea-hypopnea syndrome (OSAHS) on the condition and prognosis of ischemic stroke. Methods 18 patients with OSAHS with ischemic stroke (group A) and 20 patients with ischemic stroke (group B) were enrolled in the First Affiliated Hospital of China Medical University from October 2010 to January 2011. Blood routine, Coagulation of three, D-dimer, blood lipids, and further analysis of the above indicators and the severity of sleep apnea correlation. Results The age, gender, body mass index (BMI), the proportion of hypertension, RBC, Hb, MCV, PLT, PCT, There was no significant difference in blood lipids between the two groups. The prothrombin time (PT) and activated partial thromboplastin time (APTT) in group A were lower than those in group B, and fibrinogen (Fg) and D-dimer were higher in group A than those in group B . Analysis of group A found that the correlation coefficient (r) between oxygen reduction index (ODI) and Fg was 0.466, the percentage of total oxygen saturation less than 90% of total sleep time (T90%) was positively correlated with Fg (r = 0.535, P <0.05). There was a positive correlation between D-dimer and T80% (r = 0.529, P <0.05) and a negative correlation with night minimum oxygen saturation (r = -0.604, P <0.01). Conclusion OSAHS has an effect on coagulation index in patients with ischemic stroke and can promote hypercoagulability in blood.