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目的:观察补肾活血汤联合钙尔奇D治疗对绝经后骨质疏松症患者骨转化的影响。方法:将58例绝经后骨质疏松症患者随机分为对照组和实验组,每组29例。对照组给予钙尔奇D治疗,实验组在钙尔奇D的治疗基础上加补肾活血汤。观察2组治疗前后骨密度值及骨特异性碱性磷酸酶(B-ALP)、骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP)、尿脱氧吡啶啉(DPD)水平的变化。结果:同组治疗前后的骨密度值及治疗后组间骨密度值比较,差异均无统计学意义(P>0.05)。治疗后,2组BALP、BGP水平均较治疗前降低(P<0.05);实验组的BGP水平比对照组下降更明显(P<0.05)。治疗后2组B-ALP水平比较,差异无统计学意义(P>0.05)。治疗后,实验组TRACP、DPD水平均较治疗前降低(P<0.05);对照组TRACP、DPD水平与治疗前比较,差异均无统计学意义(P>0.05)。结论:补肾活血汤联合钙尔奇D能改善绝经后骨质疏松症患者的骨转化情况。
Objective: To observe the effect of Bushen Huoxue Decoction combined with Calcium D treatment on bone turnover in postmenopausal osteoporosis patients. Methods: 58 cases of postmenopausal osteoporosis were randomly divided into control group and experimental group, with 29 cases in each group. The control group was given Calcium D treatment, and the experimental group was given Kidney Huoxue Decoction on the basis of the treatment of Calcium D. The changes of BMD and B-ALP, BGP, TRACP, DPD were observed before and after treatment. Results: There was no significant difference in BMD between the same group before and after treatment and BMD after treatment (P> 0.05). After treatment, the levels of BALP and BGP in both groups were lower than those before treatment (P <0.05). The BGP level in the experimental group was significantly lower than that in the control group (P <0.05). There was no significant difference in B-ALP level between the two groups after treatment (P> 0.05). After treatment, the levels of TRACP and DPD in the experimental group were lower than those before treatment (P <0.05). There was no significant difference in TRACP and DPD levels between the two groups (P> 0.05). Conclusion: Bushen Huoxue decoction combined with Calcium D can improve the bone turnover in postmenopausal osteoporosis patients.