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患者男,20岁,因乏力伴双下肢肿胀2月,于1999年5月6日入院。既往无药物不良反应史。入院后迅速确诊为慢性粒细胞性白血病。查CMV(巨细胞病毒)-IgG(-),IgM(-)。1999年11月15日行异基因周血干细胞移植术,供者为其母亲,HLA配型相合,CMV—IgG(+),IgM(+)。预处理方案为环磷酰胺(120mg/kg)加全身照射(4.0Gy×3),肺部剂量 750cGy。输入 MNC(单核细胞)3.3×10~8/kg,CD_(34)~+CD_(38)~+11.8×10~6/kg。用环孢素A、氯甲蝶呤预防移植物抗宿主病(GVHD)。移植后第20天(199年12月5 日)发生急性GVHD,予甲基强的松龙治疗。1999年12月9日
Male patient, 20 years old, due to weakness with swelling of both lower extremities in February, was admitted on May 6, 1999. Past history of adverse drug reactions. Rapid diagnosis of chronic myeloid leukemia after admission. Check CMV (cytomegalovirus) -IgG (-), IgM (-). On November 15, 1999, allogeneic peripheral blood stem cell transplantation was performed. The donor was his mother, HLA matching, CMV-IgG (+) and IgM (+). The pretreatment regimen was cyclophosphamide (120 mg / kg) plus total body irradiation (4.0 Gy x 3) and a pulmonary dose of 750 cGy. MNC (mononuclear cells) was injected at a dose of 3.3 × 10 -8 / kg and CD 34 + CD 38 + 11.8 × 10 6 / kg. Cyclosporin A and methotrexate prevent graft versus host disease (GVHD). On the 20th day after transplantation (December 5, 19999), acute GVHD occurred and methylprednisolone therapy was administered. December 9, 1999