目的:观察以经尿道膀胱肿瘤切除术(TUR-Bt)为主的多模式疗法治疗局限性肌层浸润性膀胱癌(MIBC)的疗效。方法:选取2011年1月至2015年12月阳泉煤业(集团)有限责任公司总医院收治的局限性MIBC患者89例为研究对象，89例患者均行TUR-Bt，其中有40例行以TUR-Bt为主的多模式治疗，设为观察组，患者TUR-Bt术后2周开始行2～3个疗程的辅助化疗，之后根据盆腔影像学检查结果决定是否行放疗；其余49例患者行根治性膀胱切除术(RC)为对照组。比较两组的临床病理资料和复发率。结果:全部89例患者中男67例，女22例；年龄(67.0±11.0)岁；术前T分期：T2期50例、T3期39例；病理分级：G1级30例、G2级30例、G3级29例。两组的临床病理资料差异均无统计学意义(χn 2＝0.003，n t＝1.687，χn 2＝0.051、0.922，n P＝0.956、0.096、0.821、0.662)。观察组患者术后1、3年内分别有12例、20例复发，复发率分别为30.0%、50.0%，与对照组的22.4%、42.9%比较，差异均无统计学意义(χn 2＝0.655、0.573，n P＝0.418、0.449)。观察组中，术前T2期患者的术后3年复发率为34.8%，显著低于T3期患者的70.6%，差异有统计学意义(χn 2＝5.013，n P＝0.025)。n 结论:对于局限性MIBC而言，以TUR-Bt为主的多模式治疗能取得与RC相似的疗效，术后1、3年的复发风险相近。“,”Objective:To investigate the effect of multimodal therapy based on transurethral resection of bladder tumor (TUR-Bt) on locally muscle invasive bladder cancer (MIBC).Methods:From January 2011 to December 2015, 89 patients with locally MIBC in the General Hospital of Shanxi Yangquan Yangmei Group were enrolled in the study.Among them, 40 cases underwent multimodal therapy based on TUR-Bt and classified as observation group, including adjuvant chemotherapy with 2~3 courses at 2 weeks after TUR-Bt and radiotherapy according to pelvic imaging examination results.The other 49 cases underwent radical cystectomy (RC) were classified as control group.The clinical pathological data and recurrence rate were compared between the two groups.Results:Of 89 patients, 67 cases were male and 22 cases were female, aged (67.0±11.0)years.The preoperative T stage: 50 cases in T2 stage and 39 cases in T3 stage; pathological grade: 30 cases in G1, 30 cases in G2, and 29 cases in G3.There were no statistically significant differences in clinical pathological data between the two groups (χn 2=0.003, n t=1.687, χ n 2=0.051, 0.922, n P=0.956, 0.096, 0.821, 0.662). In the observation group, there were 12 cases and 20 cases had recurrence within 1 and 3 years, respectively, and the incidence were 30.0% and 50.0%.Compared with 22.4% and 42.9% of the control group, there was no statistically significant difference (χn 2=0.655, 0.573, n P=0.418, 0.449). In the observation group, the 3-year recurrence rate of patients with T2 before surgery was 34.8%, which was significantly lower than 70.6% of patients with T3, and the difference was statistically significant (χn 2=5.013, n P=0.025).n Conclusion:For locally MIBC, multimodal treatment based on TUR-Bt can achieve similar efficacy with RC, and they have similar risk of recurrence at 1 and 3 years after operation.