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分别以巯基乙酸(Mercaptoacetic Acid,MA)、还原型谷胱甘肽(Glutathione,GSH)为稳定剂在水相中直接合成了巯基乙酸CdTe(CdTe-MA)、红色巯基乙酸CdTe/CdS(CdTe/CdS-MA)、巯基乙酸CdTe/ZnS(CdTe/ZnS-MA)及谷胱甘肽CdTe(CdTe-GSH)量子点.其中,CdTe-GSH量子点的量子产率可达47.3%.体外溶血实验证实CdTe/ZnS-MA和CdTe-GSH量子点的溶血率较CdTe-MA和CdTe/CdS-MA低,浓度为0.05mmol/L的量子点溶血率<5%,达到了生物医用材料的要求.活体实验证实:通过尾静脉方式把量子点注入小鼠体内后,荧光显微镜观察发现高剂量的量子点(0.4mmol/10g)在体内主要在心、肝、脾、肾组织中分布较多,且引起不同程度的组织病变.
The thioglycolic acid CdTe (CdTe-MA) and the red thioglycolic acid CdTe / CdS (CdTe / CdS) were directly synthesized in aqueous solution with Mercaptoacetic Acid (MA) and Glutathione (GSH) CdS-MA), CdTe / ZnS (CdTe / ZnS-MA) and CdTe-GSH quantum dots, of which the quantum yield of CdTe-GSH quantum dots can reach 47.3% .In vitro hemolysis experiment The hemolysis rate of CdTe / ZnS-MA and CdTe-GSH quantum dots was lower than that of CdTe-MA and CdTe / CdS-MA. The hemolysis rate of quantum dots with the concentration of 0.05mmol / L was less than 5%, which met the requirements of biomedical materials. In vivo experiments showed that the QDs (0.4mmol / 10g) were mainly distributed in the heart, liver, spleen and kidney tissues by fluorescence microscopy after the QDs were injected into the mice via tail vein. Different degrees of tissue disease.