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免疫缺陷小鼠是研究肿瘤理想的动物模型,它的免疫系统部分缺陷,对体外移植物排斥较低的特点使其成为人类肿瘤移植的最佳选择。目前各类肿瘤的动物模型已相继建立,并运用于药物敏感性评价、抗肿瘤新药物临床前试验等研究。本文就人肿瘤异种移植动物模型的建立及应用予以综述。
Immunodeficient mice are an ideal animal model for studying tumors. Some of their immune system defects and their low rejection of extracorporeal grafts make them the best choice for human tumor transplants. At present, all kinds of tumor animal models have been established, and used in drug sensitivity evaluation, preclinical testing of new anti-tumor drugs. This article reviews the establishment and application of human tumor xenograft animal model.