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局部麻醉在眼科手术中较常用。大多数的局麻药都有一个与乙酰胆碱相类似的结构、故其阻断神经传导作用可能是通过与乙酰胆碱竞争受体蛋白而实现的。局麻药一般分为两类:一类为酯环类,如可卡因(Cocaine),丁卡因(Tetracaine)及普鲁卡因(Procaine);另一类为酰胺环类,如利多卡因(Lidocaine)和甲吡卡因(Mepivacaine)。迄今为止可卡因是人们所熟知的抑制肾上腺素能神经未梢摄取去甲肾上腺素,从而对儿茶酚胺敏感这一过程的唯一局麻药。本研究的目的在于判定与可卡因结构相似的丁卡因和普鲁卡因对眼压有无影响。本研究包括59名男女志愿者,均无眼病,年龄10～70岁,分为二组:第一组17人34眼用0.5%Proparacaine Hydrochloride滴眼3次,每次一滴,
Local anesthesia is more commonly used in ophthalmic surgery. Most local anesthetics have a structure similar to that of acetylcholine, so blocking neurotransmission may be achieved by competing with acetylcholine for the receptor protein. Local anesthetics generally fall into two categories: one is an ester ring such as Cocaine, Tetracaine and Procaine; the other is an amide ring such as Lidocaine ) And mepivacaine. Cocaine has so far been the only local anesthetic known to inhibit the adrenergic nerves from norepinephrine ingestion, thereby being sensitive to catecholamines. The purpose of this study was to determine whether tetracaine and procaine, similar in structure to cocaine, had any effect on intraocular pressure. The study included 59 men and women volunteers, all without eye disease, aged 10 to 70 years old, divided into two groups: the first group of 34 34 eyes with 0.5% Proparacaine Hydrochloride drops 3 times a drop,