目前NMR手段已广泛应用于研究金属离子络合物的络合平衡.根据金属离子或配体的NMR参数随浓度的变化,来测得络合物的离解常数.络合平衡过程是一种动态平衡过程,如果这种过程相对于NMR时间标度是慢交换过程,就可以直接从NMR谱的积分强度计算出络合平衡常数.遗憾的是,绝大多数络合平衡的动态过程都是快交换过程,这就给NMR方法测定络合平衡常数带来一些困难. At present, NMR methods have been widely used to study the complex equilibrium of metal ion complexes. The dissociation constant of the complex is measured according to the change of the NMR parameters of the metal ions or ligands with the concentration. The complexation equilibrium process is a dynamic If this process is a slow exchange with respect to the NMR time scale, the complex equilibrium constant can be calculated directly from the integrated intensity of the NMR spectrum Unfortunately, the vast majority of complex equilibrium dynamics are fast Exchange process, which gives the NMR method to determine the complex equilibrium constant to bring some difficulties.