洋地黄类药物自Withering临床应用治疗心功能不全以来已200余年,尽管近几年来有许多新的正性肌力作用的药物相继问世,但在治疗心脏病心衰及某些心律失常方面,洋地黄类药仍是临床医生最为常用的有效药物。自1975年Cluff等提出药物相互作用信息数高达6000以来,关于药物合用及相互作用的问题,越来越引起人们的重视。一、洋地黄类与抗心律失常药1.地高辛与奎尼丁:自1978年Hooymans报告对使用地高辛患者合用奎尼丁而使血清地高辛浓度增高以来,对两药的相互作用引起关注。Leahey等认为,奎尼丁可使90%以上 Digitalis has been used for more than 200 years since Withering’s clinical treatment of cardiac insufficiency. Although many new positive inotropic drugs have come out in recent years, in the treatment of heart failure and some arrhythmias, Rehmannia drug is still the most commonly used and effective drug for clinicians. Since Cluff et al. (1975) proposed the number of drug interactions as high as 6,000, more and more people pay attention to the problem of drug combination and interaction. First, digitalis and antiarrhythmic drugs 1. Digoxin and quinidine: Hooymans report since 1978, the use of quinidine in patients with digoxin and serum digoxin concentrations increased, the two drugs each other Role of concern. Leahey so that quinidine can make more than 90%