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本文作者以前曾评定150例锂治疗不同阶段病人的甲状腺功能,结果发现,除一半病人甲状腺肿大外,特殊的抗甲状腺抗体的出现与治疗持续时间正相关。而且抗甲状腺抗体阳性病人的甲状腺刺激激素(TSH)明显增高。本文研究锂治疗过程中甲状腺功能异常的演变过程与临床的关系。方法:对原来研究的150例病人随访2年,定期做精神检查及临床检测,使血锂维持在0.5～1mmol/L范围内。除锂外,必要时可应用少量抗精神病药物、抗抑郁药、苯二氮(艹卓)类或卡马西平。2年后再评定内容包括:放
The authors previously assessed the thyroid function of 150 lithium-treated patients at various stages and found that the appearance of a specific anti-thyroid antibody was positively correlated with the duration of treatment, with the exception of thyroid enlargement in half of patients. Thyroid stimulating hormone (TSH) was also significantly increased in patients with anti-thyroid antibodies. This article investigates the relationship between the evolution of thyroid dysfunction and clinical outcomes during lithium therapy. Methods: The original study of 150 patients followed up for 2 years, regular mental examination and clinical testing to maintain blood lithium 0.5 ~ 1mmol / L range. In addition to lithium, a small amount of antipsychotics, antidepressants, benzodiazepines or carbamazepine may be used if necessary. Two years later re-assessment include: release