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毛状细胞白血病(HCL)是以一种独特的细胞形态学、临床表现及自然科学为特征的淋巴增生性疾病。临床特征包括脾大,全血细胞减少及有明显胞浆突起的圆形单核细胞(“hairy”Cells)。如同所有的恶性血液病一样,感染是常见的并发症和最主要的死因。本文33例HCL,其中18例(55%)有肺部感染。肺炎的病因学:证实细菌感染者9例,推定细菌感染者7例(即通过各种抗菌素治疗,症状及x线所见消失,但未证实病原体)。对化疗或输血呈现反应者未包括在内。未见有白血病性肺浸润。9例中7例为革兰氏阴性细菌,并由其中分离出特异细菌,此17例中有4例死亡。3例霉菌性肺炎其中2例死于势不可挡的念珠菌性败血症,第3例患血源播散性球霉菌病累及肺、肝、脾及皮肤,对两性霉
Hairy cell leukemia (HCL) is a lymphoproliferative disorder characterized by a unique cellular morphology, clinical manifestations, and natural sciences. Clinical features include splenomegaly, pancytopenia and “hairy” cells with prominent cytoplasmic processes. As with all hematologic malignancies, infection is a common complication and the leading cause of death. This article 33 cases of HCL, of which 18 cases (55%) have lung infections. Etiology of pneumonia: Confirmed 9 cases of bacterial infection, presumptive bacterial infection in 7 cases (that is, through a variety of antibiotic treatment, symptoms and disappearance of x-ray, but did not confirm the pathogen). Chemotherapy or transfusion responders were not included. No leukemia infiltration seen. Of the 9 cases, 7 were Gram-negative bacteria, from which specific bacteria were isolated, and 4 of these 17 cases died. Three of the three cases of fungal pneumonia died of overwhelming candida sepsis. The third case of disseminated globular mycosis affected the lung, liver, spleen and skin,