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目的探讨降钙素原和超敏C反应蛋白(hs-CRP)的动态变化对新生儿休克严重性和预后的相关性研究。方法选取2012年8月-2015年12月该院收治的48例新生儿休克患儿为研究对象,在入院第1天、第3天、第5天,出院或死亡前1天最后1次hs-CRP、降钙素原(PCT),器官功能衰竭评分(SOFT)评分、危重评分(PCIS)评分,按预后分为死亡组和正常组,并进行SOFT评分和hs-CRP与SOFT评分、PCIS评分相关性分析。结果第1天,死亡组和存活组PCT和hs-CRP比较差异无统计学意义;死亡组第3天、第5天和最后1次,PCT和CRP和存活组比较差异有统计学意义(P<0.05),死亡组明显高于存活组。CRP和PCT与SOFT评分呈正相关,PCIS呈负相关。结论降钙素原联合hs-CRP对新生儿休克危重和预后有很好地指导意义。
Objective To investigate the correlation between dynamic changes of procalcitonin and hs-CRP in septic shock and prognosis in neonates. Methods Forty eight neonates with shock in our hospital from August 2012 to December 2015 were enrolled in this study. The patients were admitted to hospital on the first day, the third day, the fifth day, the last one day before discharge or death CRP, PCP, SOFT score and PCIS scores were divided into death group and normal group according to prognosis, and SOFT score, hs-CRP and SOFT score, PCIS score Score correlation analysis. Results There was no significant difference in PCT and hs-CRP between death group and survival group on day 1; there was significant difference between PCT group and survival group on day 3, 5 and 1 <0.05), the death group was significantly higher than the survival group. There was a positive correlation between CRP, PCT and SOFT score and PCIS. Conclusion The combination of procalcitonin and hs-CRP has a good guiding significance for the criticality and prognosis of shock in neonates.