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以雌二醇（Ｅ＿２）阴道栓剂为阳性对照，雌三醇（Ｅ＿３）阴道栓剂对去卵巢大鼠阴道粘膜作用的效价为４．５８％；对去卵巢小鼠阴道粘膜作用的效价为２０．２７％；而对小鼠子宫增重作用的效价为３．４％，表明Ｅ＿３栓剂阴道给药对小鼠阴道粘膜作用较强而对子宫增重作用较弱。
The vaginal suppository of estradiol (E_2) was the positive control. The potency of vaginal suppository of estriol (E_3) on vaginal mucosa in ovariectomized rats was 4.58%. The potency of vaginal mucosa in ovariectomized mice was 20.27% respectively; while the titer of mouse uterus weight gain was 3.4%, indicating that vaginal administration of E 3 suppository had a strong effect on vaginal mucosa and weak effect on uterine weight gain.