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目的:研究白芍总苷对糜烂型口腔扁平苔藓外周血肿瘤坏死因子(TNF-α)、γ-干扰素(IFN-γ)及白细胞介素-10(IL-10)水平的影响。方法:选取2014年7月至2015年7月我院接诊的糜烂型口腔扁平苔藓患者80例作为本次研究对象。对照组患者采用低浓度他克莫司治疗,观察组采用白芍总苷治疗,观察两组患者治疗前后血清TNF-α、IFN-γ及IL-10水平的变化、糜烂面积、疼痛评分及近期治疗疗效。结果:治疗后,观察组血清TNF-α、IL-10水平显著低于对照组,血清IFN-γ水平明显高于对照组[(2.16±0.61)μg/m L vs(3.04±0.80)μg/m L、(258.93±5.72)ng/L vs(273.41±6.03)ng/L、(319.27±53.46)ng/L vs(290.95±51.03)ng/L(P<0.05),糜烂面积、疼痛评分均显著低于对照组[(0.10±0.03)cm2 vs(0.51±0.10)cm~2、(1.01±0.30)分vs(3.20±0.78)分](P<0.05),近期治疗疗效优于对照组95.00%(38/40)vs75.00%(30/40)(P<0.05)。结论:白芍总苷治疗糜烂型口腔扁平苔藓的效果显著,可能与其调节血清TNF-α、IFN-γ及IL-10的水平有关。
Objective: To study the effects of total glucosides of paeony on the level of tumor necrosis factor (TNF-α), interferon-γ (IFN-γ) and interleukin-10 (IL-10) in peripheral blood of erosive oral lichen planus. Methods: From July 2014 to July 2015, 80 patients with erosive oral lichen planus in our hospital were selected as the study object. The patients in the control group were treated with low concentration of tacrolimus, the patients in the observation group were treated with total glucosides of paeony. The changes of serum TNF-α, IFN-γ and IL-10 levels, erosion area, pain scores and the recent Therapeutic effect. Results: After treatment, the level of serum TNF-α and IL-10 in the observation group was significantly lower than that in the control group, and the level of serum IFN-γ in the observation group was significantly higher than that in the control group [(2.16 ± 0.61) μg / m L vs (3.04 ± 0.80) μg / (258.93 ± 5.72) ng / L vs (273.41 ± 6.03) ng / L, (319.27 ± 53.46) ng / L vs (290.95 ± 51.03) ng / L, P <0.05) (1.01 ± 0.30) vs (3.20 ± 0.78) points (P <0.05) in the control group [(0.10 ± 0.03) cm2 vs (0.51 ± 0.10) cm ~ % (38/40) vs 75.00% (30/40) (P <0.05). CONCLUSION: Total glucosides of paeony have significant effect on erosive oral lichen planus, which may be related to the regulation of serum levels of TNF-α, IFN-γ and IL-10.