目的:探讨应用负压封闭技术辅助修复下肢难愈性创面的效果。方法:对6例患者10个不同创面通过彻底清创,并采用封闭式持续负压吸引治疗,按创面清创有效标准进行观察评估治疗效果。结果:经过5～7天封闭式持续负压吸引治疗,创面缩小20%～30%,原感染创面细菌培养均转为阴性,创面清洁时间为5～10天,肉芽组织生长新鲜,血循环良好,4例10～14天创面平坦,表面上皮化愈合,2例转外科植皮及皮瓣转移后创面愈合。结论:封闭式负压吸引能够促进下肢难愈性创面的愈合,减少病人痛苦,减轻医务人员工作量,是一种简单、安全、有效的治疗方法。 Objective: To explore the effect of using negative pressure occlusion technique to repair the refractory lower extremity wounds. Methods: Thirteen different wounds were completely debrided in 6 patients and were treated with closed continuous negative pressure to observe the therapeutic effect according to the effective standard of wound debridement. Results: After 5 to 7 days of continuous negative suction therapy, the wound area was reduced by 20% -30%. The bacterial cultures of the original infected wounds turned negative, the wound cleaning time was 5 to 10 days, the granulation tissue grew freshly, blood circulation was good, In 4 cases, the wounds were flat on the 10th to 14th day, the surface was healed by epithelialization, and the wounds healed after 2 cases of surgical grafts and skin flap metastases. Conclusion: Closed vacuum suction can promote the healing of lower limb refractory wounds, reduce the pain of patients and reduce the workload of medical staff, which is a simple, safe and effective treatment.