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目的:通过用药的不同时段,观察评价加味甘草干姜汤对变应性鼻炎大鼠咽部黏膜形态学的变化情况。方法:将SD大鼠90只随机分为正常对照组、加味甘草干姜汤组、模型对照组共三组,各30只,后两组用卵清蛋白(AVO)对大鼠行实验性变应性鼻炎造模,造模成功后加味甘草干姜汤组予加味甘草干姜汤2~2.5ml/只灌胃,剩余两组大鼠予2~2.5ml/只生理盐水灌胃,每天1次;各组分别在灌胃10天、20天、30天三个时段处死10只大鼠,观察咽部黏膜的变化。结果:HE染色示:加味甘草干姜汤组经过30天的灌胃治疗后,咽部黏膜结构逐渐修复,炎症细胞显著减少。结论:甘草干姜汤对变应性大鼠咽部黏膜炎症反应有一定抑制与修复作用。
OBJECTIVE: To observe and evaluate the change of pharyngeal mucosa morphological changes in rats with allergic rhinitis through different periods of medication. Methods: Ninety Sprague-Dawley rats were randomly divided into normal control group, flavored licorice dry ginger soup group and model control group, with 30 rats in each group. The latter two groups were treated with ovalbumin (AVO) Should be made of rhinitis model, after the success of modeling add flavored licorice dry ginger group to add licorice dry ginger 2 ~ 2.5ml / only gavage, the remaining two groups of rats to 2 ~ 2.5ml / normal saline, 1 The rats in each group were sacrificed at 10 days, 20 days and 30 days respectively. Ten rats were sacrificed to observe the changes of pharyngeal mucosa. Results: The results of HE staining showed that the mucosal structure of the pharynx was gradually repaired and the number of inflammatory cells was significantly reduced after the gavage treatment of Ganjiang Decoction for 30 days. Conclusion: Licorice Ginger Decoction can inhibit and repair inflammation of pharyngeal mucosa in allergic rats.