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目的探讨Castleman病的临床特征、实验室检查特点及治疗方案。方法回顾性分析8例Castleman病的临床表现、实验室检查、治疗及疗效评价。结果 8例患者中4例首发症状有乏力,3例有低蛋白血症,3例有蛋白尿或者肾损害,2例有感染,1例有肌损害。3例确诊为透明血管型,3例为浆细胞型,2例为混合细胞型。病理学提示淋巴结结构保持完整,滤泡增生明显,血管增生。结论 Castleman病临床表现无特异性,其诊断和分型主要依靠组织病理学,手术、化疗、放疗及生物治疗等多种方法可应用于该病的治疗。
Objective To investigate the clinical features, laboratory features and treatment of Castleman’s disease. Methods Retrospective analysis of 8 cases of Castleman’s disease clinical manifestations, laboratory tests, treatment and efficacy evaluation. Results Of the 8 patients, 4 had first symptoms of fatigue, 3 had hypoproteinemia, 3 had proteinuria or renal damage, 2 had infection, and 1 had muscle damage. Three cases were diagnosed as clear blood vessel type, three were plasmacytoma type and two were mixed cell type. Pathology suggests that the structure of lymph nodes remain intact, follicular hyperplasia, vascular hyperplasia. Conclusion The clinical manifestations of Castleman disease are non-specific. The diagnosis and classification of Castleman’s disease can be applied to treat the disease mainly by histopathology, surgery, chemotherapy, radiotherapy and biological therapy.