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目的探讨牛磺酸熊去氧胆酸治疗慢性乙型肝炎重叠戊型肝炎感染的效果。方法选择2014年4月—2015年8月收治的慢性乙型肝炎重叠戊型肝炎感染患者90例,将所有患者按照随机数字表法分为观察组与对照组,每组45例。给予对照组常规保肝治疗和恩替卡韦口服。在对照组的基础上给予观察组牛磺酸熊去氧胆酸口服。两组均用药6个月。比较两组治疗前后的肝功能指标、疗效、住院时间和病死率。计量资料比较采用t检验,计数资料比较采用χ~2检验。P<0.05为差异有统计学意义。结果治疗6个月后,观察组丙氨酸氨基转移酶(ALT)、血清胆红素(TBIL)、天冬氨酸转氨酶(AST)均低于对照组,白蛋白(ALB)高于对照组,差异有统计学意义(均P<0.05)。观察组治疗总有效率93.3%高于对照组77.8%,观察组死亡率4.4%低于对照组17.8%,住院时间短于对照组,比较差异有统计学意义(均P<0.05)。结论牛磺酸熊去氧胆酸治疗慢性乙型肝炎重叠戊型肝炎感染疗效确切,可明显改善患者的肝功能。
Objective To investigate the effect of taurodeoxycholic acid in the treatment of overlapping hepatitis E infection in chronic hepatitis B patients. Methods Ninety patients with overlapping hepatitis E infection from April 2014 to August 2015 were enrolled in this study. All patients were divided into observation group and control group according to random number table method, with 45 cases in each group. Give the control group conventional liver protection and oral entecavir. On the basis of the control group, the observation group was given taurodeoxycholic acid orally. Both groups were treated for 6 months. The liver function indexes, efficacy, hospitalization time and mortality of the two groups before and after treatment were compared. Measurement data were compared using t test, count data were compared using χ ~ 2 test. P <0.05 for the difference was statistically significant. Results After six months’ treatment, the levels of ALT, TBIL and AST in the observation group were lower than those in the control group, while the levels of albumin (ALB) in the observation group were higher than those in the control group , The difference was statistically significant (both P <0.05). The total effective rate in the observation group was 93.3% higher than that in the control group (77.8%). The mortality rate in the observation group was 4.4% lower than that in the control group (17.8%). The length of stay in the observation group was shorter than that in the control group (all P <0.05). Conclusion Tauroursodeoxycholic acid treatment of chronic hepatitis B overlap hepatitis E infection curative effect is exact, can significantly improve the patient’s liver function.