目的　研究箬叶多糖及其衍生物硫酸酯多糖和硒酸酯多糖对小鼠艾滋病的治疗作用。方法　采用 Ｌ Ｐ Ｂ Ｍ５ 鼠白血病病毒（ Ｍｕ Ｌ Ｖ） 感染 Ｃ５７ Ｂ Ｌ／６ Ｊ 小鼠的方法建立艾滋病模型。结果　硫酸酯多糖５０ ｍｇ·ｋｇ － １·ｄ － １（ｉｐ） 具有较好地抑制小鼠脾肿大、血清 Ｉｇ Ｇ 增高的作用，硒酸酯多糖在两种给药方式中有一定的保护作用。此外，还首次发现感染小鼠出现 Ｇ Ｓ Ｈ Ｐｘ 活力下降，脂质过氧化产物升高，这与 Ｈ Ｉ Ｖ感染的病人的症状是一致的，硒多糖对提高机体的抗氧化功能有较好的作用。多糖经硫酸酯化、硒酸酯化等化学修饰后，活性有不同程度的提高。结论　作为抗氧化剂和免疫增强剂的微量元素硒和多糖类可能对 Ｈ Ｉ Ｖ 感染的病人有一定的治疗作用 Objective To study the therapeutic effect of polysaccharide sulfate and its derivatives sulfated polysaccharide and selenate polysaccharide on AIDS in mice. Methods The AIDS model was established by infecting C57 B L / 6 J mice with LpB M5 murine leukemia virus (Mu L V). Results Sulfate polysaccharide 50 mg · kg - 1 · d - 1 (ip) could inhibit splenomegaly and increase serum Ig G in mice. Selenopolysaccharide has certain protection in both modes of administration effect. In addition, it was also found for the first time in mice infected with G S H Px decreased vitality, lipid peroxidation products, which is consistent with the symptoms of H I V infection in patients with selenium polysaccharide to improve the body’s antioxidant function than Good effect. Polysaccharide by sulfuric acid esterification, selenization and chemical modification, the activity increased in varying degrees. Conclusions Selenium and polysaccharides, trace elements as antioxidants and immunostimulants, may have therapeutic effects on patients with H I V infection