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1965年Ramirez—R成功地应用大容量全肺灌洗(Massire pulmonary lavage)治疗肺泡蛋白沉积症后,一些学者相继将这一方法用于治疗一些其他肺疾病,如囊肿性肺纤维化,吸入性肺炎、卡氏肺囊虫感染、肺脓肿、慢性肺炎、肺泡微石症、哮喘性支气管炎、支气管扩张和粘液粘稠病等,均取得一定疗效。1982年 Mason 等对一例混合性矽肺患者施行两侧全肺灌洗,获显著效果。由于 Ramirez—R 的方法易引起低氧血症,未能广泛应用。本文对 Ramirez—R 的方法进行了一些改进,对10例尘肺患者施行了18次单侧全肺灌洗治疗,取得了明显的近期疗效,现作初步报告,并对大容量全肺灌洗治疗的方法学与疗效机理进行一些探讨。
After Ramirez-R successfully applied Massire pulmonary lavage to alveolar proteinosis in 1965, some scholars have used this method one after another to treat some other lung diseases such as cystic fibrosis, inhalation Pneumonia, Pneumocystis carinii infection, lung abscess, chronic pneumonia, alveolar microlithiasis, asthmatic bronchitis, bronchiectasis and mucoviscidosis, have achieved a certain effect. In 1982 Mason and other patients with mixed silicosis on both sides of the whole lung lavage, a significant effect. Due to Ramirez-R’s method can easily lead to hypoxemia, not widely used. In this paper, Ramirez-R method was improved, 10 cases of pneumoconiosis patients were administered 18 times unilateral whole lung lavage treatment, and achieved significant short-term efficacy, the initial report is now made, and the large-capacity whole lung lavage treatment The methodology and efficacy of the mechanism of some discussion.