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肿瘤组织的分子生物学分析可用于调查不同类型肿瘤的病因及其他相似性。食管癌和贲门癌有一些值得注意的病理学和流行病学相似点,但贲门癌是否应归类于食管腺癌仍有争议。此研究用食管、贲门和贲门周围腺癌的肿瘤组织中p53基因突变的类型和频率,来调查三者之间的基因学相似处,并确定食管癌和贲门癌组织中p53基因突变的存在对这些患者预后的意义及其他重要临床意义。
Molecular biology of tumor tissue can be used to investigate the etiology and other similarities of different types of tumors. Esophageal and cardia cancers have some noteworthy pathological and epidemiological similarities, but whether cardia cancer should be classified as esophageal adenocarcinoma remains controversial. The purpose of this study was to investigate the presence of p53 gene mutations in esophageal and cardia cancers using the types and frequencies of p53 mutations in the tumor tissues of esophageal, cardia and adenocarcinoma of the cardia The significance of these patients prognosis and other important clinical significance.