Gilbert’s综合征又称先天性非溶血性黄疸(间接胆红素增高型)或体质性肝功能不良性黄疸,其病因未明,一般认为是由于肝细胞内葡萄糖醛酰转移酶功能不足所引起。采用苯巴比妥等酶诱导药物治疗可缓解病情,但有一定副作用。本文报告用导眠能(Glutethimide)治疗二例Gilbert’s综合征,疗效满意,用药后黄疸明显消退,血清胆红素显著下降,且未见副作用。例1 杨××,女,20岁,住院号213060,1976年起自觉劳动后易疲乏、腹胀、尿色黄,曾疑为“肝炎”, Gilbert’s syndrome, also known as congenital non-hemolytic jaundice (indirect bilirubin increased type) or constitutional dyslipidemia jaundice, its etiology is unknown, generally believed to be due to liver cell glucuronyltransferase deficiency caused. The use of phenobarbital and other enzyme-induced drug therapy can alleviate the disease, but there are some side effects. This article reports the use of Glutethimide in the treatment of two Gilbert’s syndromes, with satisfactory results. Jaundice subsides significantly after treatment, and serum bilirubin is significantly reduced with no side effects. Example 1 Yang × ×, female, 20 years old, hospitalized 213060, since 1976, fatigue after work, abdominal distension, urine yellow, had suspected “hepatitis”