论文部分内容阅读
目的通过观察65例短暂性脑缺血发作(TIA)患者的认知能力、血清促红细胞生成素(EPO)、神经元特异性烯醇化酶(NSE)及亮氨酸-脑啡肽(L-EK)水平变化,以探讨以上神经肽、TIA发作次数与认知障碍的关系。方法选择最后1次发作在72h内的TIA患者,按照中国卒中量表(CSS)于入院当天进行现场或回顾性神经功能缺损程度评分,根据简易智力状态量表(MMSE)对患者组及对照组的认知能力进行测评;采用放免法测定血清神经肽EPO、NSE、L-EK水平,分析各种神经肽、TIA发作次数与患者认知能力的关系。结果患者组的MMSE明显低于对照组(P<0.01);患者组血清EPO、NSE、L-KE水平均明显高于对照组(P分别<0.05,0.01,0.05),且在不同认知能力损害组血清L-EK、NSE水平存在显著差异;不同发作次数的TIA患者MMSE及CSS明显不同。结论观察TIA的发作次数及测定TIA患者血清L-EK及NSE水平可能对判断患者认知障碍程度具有重要价值。
Objective To investigate the cognitive ability, serum erythropoietin (EPO), neuron specific enolase (NSE) and leucine-enkephalin (L-) in 65 patients with transient ischemic attack (TIA) EK) levels to explore the above neuropeptide, the number of TIA seizures and cognitive disorders. Methods TIA patients with the last episode within 72 hours were scored according to the China Stroke Scale (CSS) on the day of admission or retrospective neurological deficit. According to the MMSE, The levels of EPO, NSE and L-EK in serum were measured by radioimmunoassay. The relationship between the number of neuropeptides and TIA seizure and the cognitive ability of patients were analyzed. Results The MMSE in patients was significantly lower than that in controls (P <0.01). The levels of serum EPO, NSE and L-KE in patients were significantly higher than those in controls (P <0.05,0.01,0.05 respectively) There were significant differences in the levels of serum L-EK and NSE between the two groups. MMSE and CSS were significantly different in different episodes of TIA. Conclusions The number of episodes of TIA and the determination of serum levels of L-EK and NSE in patients with TIA may be of great value in judging the degree of cognitive impairment in patients.