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目的观察化痰通络方联合阿托伐他汀钙片治疗颈动脉粥样硬化的临床疗效。方法将60例颈动脉粥样硬化的患者随机分为两组,每组30例。治疗组给予化痰通络方联合阿托伐他汀钙片治疗,对照组仅给予阿托伐他汀钙片治疗,治疗6个月后观察患者治疗前后的颈动脉内中膜厚度(IMT)、颈动脉斑块的Crouse积分、血清胆固醇(TC)、血清甘油三酯(TG)、血清低密度脂蛋白(LDL-C)及中医临床症状。结果治疗后两组的颈动脉内中膜厚度(IMT)、颈动脉斑块的Crouse积分、血清胆固醇(TC)、血清甘油三酯(TG)、血清低密度脂蛋白(LDL-C)各项指标均较治疗前有所下降(P<0.05),中医临床症状亦有所改善,且治疗组的各项指标较对照组下降更显著(P<0.05),中医临床症状改善的更明显(P<0.05)。结论化痰通络方联合阿托伐他汀钙片治疗颈动脉粥样硬化的临床疗效显著。
Objective To observe the clinical efficacy of Huatan Tongluo Decoction combined with atorvastatin calcium in the treatment of carotid atherosclerosis. Methods Sixty patients with carotid atherosclerosis were randomly divided into two groups (n = 30 in each group). The treatment group was treated with Huatan Tongluo Decoction combined with atorvastatin calcium tablets, while the control group only with atorvastatin calcium tablets. After 6 months’ treatment, the carotid intima-media thickness (IMT), neck Crouse score of arterial plaque, serum cholesterol (TC), serum triglyceride (TG), serum low density lipoprotein (LDL-C) and TCM clinical symptoms. Results After treatment, IMT, Crouse score, TC, TG and LDL-C (P <0.05), clinical symptoms of TCM also improved, and the indexes in the treatment group decreased more significantly than those in the control group (P <0.05), while the clinical symptoms in the TCM group improved more obviously (P <0.05) <0.05). Conclusion Huatan Tongluo combined with atorvastatin calcium tablets in the treatment of carotid atherosclerosis clinical efficacy significantly.