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目的探讨呼吸机所致的肺损伤因素与肺保护性策略。方法将我院2004年2月～2006年11月将使用呼吸机并出现肺损伤的21例患者作为A组,另随机选出27例病情一致(肺损伤评分、APACHEⅡ)用呼吸机治疗而无肺损伤的患者作为B组,进行回顾性分析比较两组患者的气道压力、潮气量、PEEP与PaCO_2、中性粒细胞、呼吸频率和吸气流速。结果A组中的气道压力、潮气量、流速和中性粒细胞要高于B组。而B组病人一般存在高碳酸血症。结论低潮气量、低流速、适当的PEEP、允许性的高碳酸血症有助于预防呼吸机所致的肺损伤。值得临床推广。
Objective To investigate the ventilator-induced lung injury and lung protection strategies. Methods From February 2004 to November 2006, 21 patients with ventilator and lung injury in our hospital were enrolled as group A. 27 patients were randomly selected (APACHE II, APACHE II) with ventilator and no The patients with lung injury as group B were analyzed retrospectively to compare airway pressure, tidal volume, PEEP and PaCO 2, neutrophils, respiratory rate and inspiratory flow rate in both groups. Results The airway pressure, tidal volume, flow velocity and neutrophils in group A were higher than those in group B. The group B patients generally hypercapnia. Conclusions Low tidal volume, low flow rate, appropriate PEEP, and permissive hypercapnia help prevent ventilator-induced lung injury. Worth clinical promotion.