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目的观察热疗联合同步放化疗治疗中晚期食管癌的近期疗效、毒副反应。方法 132例不能手术或不同意手术的中晚期食管癌患者,随机分成两组,每组66例,治疗组应用深部热疗联合同步放化疗,对照组应用同步放化疗,比较两组近期疗效和不良反应。结果近期疗效全部病例均完成治疗,无退组病例。治疗组和对照组总疗效分别为90.9%和69.7%,治疗组近期疗效高于对照组,差异有统计学意义(P<0.05);治疗组在骨髓抑制、胃肠道反应及放射性食管炎发生率方面均低于对照组,差异有统计学意义(P<0.05)。结论热疗联合同步放化疗治疗中晚期食管癌疗效优于同步放化疗,并且降低了放化疗的不良反应,值得进一步探讨。
Objective To observe the short-term curative effect and toxicity of hyperthermia combined with concurrent chemoradiotherapy in the treatment of advanced esophageal cancer. Methods A total of 132 patients with advanced esophageal cancer who could not be operated or did not agree with surgery were randomly divided into two groups with 66 cases in each group. Deep hyperthermia combined with concurrent radiotherapy and chemotherapy was used in the treatment group and concurrent chemoradiotherapy was used in the control group. The short- Adverse reactions. Results of the recent treatment of all cases were completed treatment, no retreat cases. The total curative effect of treatment group and control group were 90.9% and 69.7%, respectively, and the curative effect in the treatment group was higher than that in the control group (P <0.05). The treatment group had myelosuppression, gastrointestinal reaction and radiation esophagitis Rate were lower than the control group, the difference was statistically significant (P <0.05). Conclusions Hyperthermia combined with concurrent chemoradiotherapy is superior to concurrent chemoradiotherapy in concurrent esophageal cancer and reduces adverse reactions of chemoradiotherapy. It deserves further exploration.