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目的观察葡萄糖毒性对初诊的糖尿病患者胰岛β细胞功能的影响。方法观察60例新诊断的糖尿病患者治疗前后空腹胰岛素、空腹胰岛素原水平。结果随血糖、糖化血红蛋白水平的下降,空腹胰岛素上升、空腹胰岛素原水平下降,比较差异均有统计学意义。结论葡萄糖毒性对胰岛β细胞功能有影响,控制血糖可改善胰岛β细胞功能。
Objective To observe the effect of glucose toxicity on pancreatic β-cell function in newly diagnosed diabetic patients. Methods The fasting insulin and fasting insulin levels in 60 newly diagnosed diabetic patients before and after treatment were observed. Results With the decline of blood glucose, HbA1c, fasting insulin and fasting plasma proinsulin, the differences were statistically significant. Conclusion Glucose toxicity has an effect on pancreatic β-cell function. Controlling blood glucose can improve pancreatic β-cell function.