虽然胚胎中脑细胞移植对帕金森病的疗效已得到广泛证实,但在这项技术广泛应用于临床之前仍有一些问题亟待解决。其中主要是移植物存活率低和宿主纹状体神经支配恢复有限。迄今为止,人们尝试了很多方法来解决这些问题,包括神经营养因子的广泛应用,以及神经和(或)非神经来源组织的联合移植。本文将对目前的胚胎中脑细胞移植术中所用的神经保护手段及其局限性进行简要的介绍。 Although the effect of embryonic mesencephalic cell transplantation on Parkinson’s disease has been widely confirmed, there are still some problems to be solved before the technology is widely used in clinical practice. Among them are the low survival rate of the graft and the limited recovery of the innervation of the host striatum. So far, many attempts have been made to solve these problems, including the widespread use of neurotrophic factors and the co-transplantation of neural and / or non-neural tissue. This article provides a brief overview of the current neuroprotective tools used in embryo meningioma cell transplantation and their limitations.