目的：观察双嘧达莫对兔心肌缺血预处理心电生理效应的影响。方法：采用新西兰兔建立心肌缺血再灌注模型，随机分为４组，其中１组为对照组，其余３组分别予以缺血预处理、双嘧达莫０２５ｍｇ／ｋｇ静脉注射和两者联合处理。应用心脏程序电刺激技术测定心室电生理参数及心室颤动阈值。结果：缺血预处理明显降低缺血再灌注损伤后心室有效不应期离散度、心室恢复时间离散度及双极心室电图ＱＴ间期离散度（分别为１５０ｍｓｖｓ２３６ｍｓ，Ｐ＜００１，１０６ｍｓｖｓ２２１ｍｓ，Ｐ＜００１，１３１ｍｓｖｓ２２９ｍｓ，Ｐ＜００１），提高心室颤动阈值（３０８ｍＡｖｓ２０６ｍＡ，Ｐ＜００１），减少室颤发生；联合应用双嘧达莫使有效不应期的离散度进一步下降（８８ｍｓｖｓ１５０ｍｓ，Ｐ＜００５），心室颤动阈值进一步提高（３６４ｍＡｖｓ３０８ｍＡ，Ｐ＜００５）。结论：缺血预处理增加心肌缺血再灌注损伤后心室电稳定性，联合应用双嘧达莫可增强缺血预处理的效应 Objective: To observe the effect of dipyridamole on myocardial electrophysiological effect of myocardial ischemic preconditioning in rabbits. Methods: The model of myocardial ischemia-reperfusion was established in New Zealand rabbits. The models were randomly divided into 4 groups, 1 group as the control group, the other 3 groups were given ischemic preconditioning, dipyridamole 0  25mg / kg intravenous injection and two Joint processing. Ventricular electrophysiological parameters and ventricular fibrillation thresholds were determined by cardiac program electrical stimulation. Results: Ischemic preconditioning significantly reduced ventricular effective refractory period dispersion, ventricular recovery time dispersion and bipolar ventricular QT dispersion (150 ms vs 236 ms, P < 001, 106msvs221ms, P <001, 131msvs229ms, P <001), and increased the threshold of ventricular fibrillation (308mA vs206mA, P <001) (88ms vs150ms, P <005), and further increase of ventricular fibrillation threshold (364mA vs 308mA, P <005) . CONCLUSION: Ischemic preconditioning increases the ventricular electrical stability after myocardial ischemia-reperfusion injury and the combination of dipyridamole can enhance the effect of ischemic preconditioning