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骨肉瘤是好发于青少年的原发性骨的恶性肿瘤,生存率低下,疗效十分不理想,即使行截肢及化疗后仍有约40%患者死于肿瘤肺转移。研究表明:80～90%的患者确诊前已经发生了全身的微病灶转移。目前,单一肺转移灶大多行手术切除,但对于多发转移灶仍没有好的方法。因此,骨肉瘤转移成为当前进一步提高生存率的瓶颈。研究骨肉瘤转移机制,对遏制骨肉瘤的生长,控制骨肉瘤转移,提高临床疗效和患者生
Osteosarcoma is a malignant tumor of primary bone that occurs in adolescents. The low survival rate results in a very poor outcome. About 40% of the patients died of tumor lung metastasis even after amputation and chemotherapy. Studies have shown that 80 to 90% of patients have had systemic micrometastasis before diagnosis. At present, most single lung metastases are surgically removed, but there is still no good method for multiple metastases. Therefore, osteosarcoma metastasis as the current bottleneck to further improve the survival rate. To study the mechanism of osteosarcoma metastasis, to inhibit the growth of osteosarcoma, to control the metastasis of osteosarcoma, to improve the clinical efficacy and patient’s health