论文部分内容阅读
目的 探讨肿瘤坏死因子 α(TNF α)和白介素 2 (IL 2 )在格林 巴利综合征 (GBS)发病机制中的作用。方法 应用ELISA双抗体夹心法 ,检测 31例GBS患者血浆TNF α和IL 2浓度。结果 31例GBS患者TNF α和IL 2浓度明显高于对照组 (P <0 .0 0 1) ,且与临床分级显著相关 (P <0 .0 5)。 16例接受糖皮质激素治疗 ,病情好转的恢复期患者TNF α和IL 2浓度相应下降至正常或接近正常。结论 本组结果提示 ,TNF α和IL 2可能直接和间接参与周围神经脱髓鞘的病理损害 ,在GBS的发病机制中起着重要用。
Objective To investigate the role of tumor necrosis factor α (TNF α) and interleukin 2 (IL 2) in the pathogenesis of Guillain-Barre syndrome (GBS). Methods The plasma levels of TNFα and IL-2 in 31 patients with GBS were detected by ELISA double antibody sandwich method. Results The concentrations of TNFα and IL-2 in 31 patients with GBS were significantly higher than those in control group (P <0.01), and were significantly correlated with clinical grade (P <0.05). In the 16 patients receiving glucocorticoid therapy, the patients with convalescent convalescence had a corresponding reduction of TNFα and IL-2 levels to normal or nearly normal. Conclusions Our results suggest that TNFα and IL-2 may be directly and indirectly involved in the pathological damage of peripheral nerve demyelination and play an important role in the pathogenesis of GBS.