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New Engl J Med于1971年提出一种假说,即肿瘤依靠血管生成而生长。由于数年来一些实验室和临床观察数据的支持,此观点目前已被广泛接受。这些研究导致发现了血管生成多肽,阐明了它们完整的氨基酸序列,并克隆了它们的基因。血管生成蛋白的分子量为5500～45000,根据它们对血管内皮的作用可以分类。一些蛋白,例如血小板衍化内皮细胞生长因子(PD-DCGF)是促有丝分裂的,趋化性的,在特殊情况下对血管上皮细胞具有两
In 1971, New Engl J Med proposed a hypothesis that tumors grow by angiogenesis. This view has now been widely accepted due to several years of laboratory and clinical observation data support. These studies led to the discovery of angiogenic polypeptides, elucidated their complete amino acid sequence, and cloned their genes. The molecular weight of angiogenic proteins ranges from 5500 to 45000 and can be classified according to their effects on the vascular endothelium. Some proteins, such as platelet-derived endothelial cell growth factor (PD-DCGF), are mitogenic, chemotaxis, and in special cases have two vascular epithelial cells.