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对氯甲基苯乙烯(CMS)在相转移催化剂(PTC)催化下,与3-巯基丙酸钾进行亲核取代反应,制备了标题化合物。研究了溶剂、催化剂及反应温度对反应的影响,实验结果表明:以二甲苯为溶剂,以三乙胺为相转移催化剂,催化剂与CMS的物质的量之比为1∶10,80℃下反应8 h,3-巯基丙酸(4-乙烯基苯基)甲酯的产率达60.7%,HPLC分析得到产物纯度>98%,1HNMR分析确证了产物结构。
Chloromethylstyrene (CMS) was subjected to nucleophilic substitution reaction with potassium 3-mercaptopropionate under the catalysis of phase transfer catalyst (PTC) to prepare the title compound. The effects of solvent, catalyst and reaction temperature on the reaction were studied. The experimental results showed that the ratio of the amount of catalyst to CMS was 1:10 at 80 ℃ with xylene as solvent and triethylamine as phase transfer catalyst The yield of 3-mercaptopropionic acid (4-vinylphenyl) methyl ester was 60.7% at 8 h. The purity of the product was> 98% by HPLC. 1H NMR analysis confirmed the product structure.