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目的探讨流产经历和子宫肌瘤家族史对子宫肌瘤患病风险的影响,为预防子宫肌瘤提出建议。方法采用病例-对照研究方法,使用结构式问卷调查的方式收集山东省城市和农村的10个县级单位20~65岁常住已婚已育女性的流产经历和子宫肌瘤家族史,同时收集其年龄、身高等信息。运用Logistic回归模型分析流产经历和子宫肌瘤家族史与子宫肌瘤的关系。应用交互作用的相对超额风险(RERI)、归因于交互作用的比例(AP)和协同指数(S)三个指标评价流产史和子宫肌瘤家族史的相加交互作用。结果多因素非条件Logistic回归模型结果显示,流产史(OR=1.39,95%CI:1.06~1.80)和子宫肌瘤家族史(OR=2.07,95%CI:1.36~3.15)均为子宫肌瘤的危险因素。流产史和子宫肌瘤家族史对子宫肌瘤患病风险存在相加交互作用(S=5.51,AP=0.59,RERI=2.14)。有子宫肌瘤家族史的研究对象,1次流产和2次以上流产经历其子宫肌瘤患病风险分别增加1.78倍和2.77倍,而无遗传背景的研究对象中,流产经历对子宫肌瘤发病影响较小。结论有子宫肌瘤遗传背景的敏感人群应注意计划怀孕,谨慎流产以降低患子宫肌瘤的风险。
Objective To investigate the influence of abortion experience and familial history of uterine fibroids on the prevalence of uterine fibroids and to provide suggestions for the prevention of uterine fibroids. Methods A case-control study was conducted to investigate the abortion experience and the family history of uterine fibroids in 10 age-dependent and fertile women between the ages of 20 and 65 in 10 county-level cities and rural areas of Shandong Province by using a structured questionnaire. Meanwhile, , Height and other information. Using Logistic regression model to analyze the relationship between abortion experience and family history of uterine fibroids and uterine fibroids. RERI, interactional proportion (AP) and synergy index (S) were used to evaluate the additive interaction between the history of miscarriage and the family history of uterine fibroids. Results The multivariate non-conditional Logistic regression model showed that the miscarriage history (OR = 1.39, 95% CI: 1.06-1.80) and family history of uterine fibroids (OR = 2.07,95% CI: 1.36-3.15) Risk factors. Abortion history and family history of uterine fibroids had an additive interaction with the risk of uterine fibroids (S = 5.51, AP = 0.59, RERI = 2.14). Familial history of uterine fibroids research object, 1 abortion and 2 or more abortions experienced a 1.78-fold and 2.77-fold increased risk of their own uterine fibroids, but no genetic background of the study, the abortion experience of uterine fibroids incidence Less affected. Conclusion The sensitive genetic background of uterine fibroids should pay attention to the planned pregnancy, cautious abortion to reduce the risk of uterine fibroids.