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目的:建立银翘解毒软胶囊的指纹图谱。方法:采用Kromasil C18色谱柱(4.6 mm×250 mm,5μm),流动相乙腈-0.1%磷酸梯度洗脱,检测波长327 nm,柱温30℃,流速1.0 mL.min-1。测定10批银翘解毒软胶囊,建立其指纹图谱。结果:指纹图谱中标记了14个共有峰,10批银翘解毒软胶囊指纹图谱相似度均>0.97。结论:该方法具有良好的精密度、重复性、稳定性,可用于银翘解毒软胶囊质量的综合评价。
Objective: To establish the fingerprints of Yinqiao Jiedu soft capsule. Methods: Kromasil C18 column (4.6 mm × 250 mm, 5 μm) was used. The mobile phase was eluted with gradient elution of acetonitrile and 0.1% phosphoric acid. The detection wavelength was 327 nm. The column temperature was 30 ℃ and the flow rate was 1.0 mL.min-1. Determination of 10 batches of Yinqiao detoxification soft capsules, the establishment of their fingerprints. Results: There were 14 common peaks in the fingerprints, and the fingerprint similarity of 10 batches of Yinqiao Jiedu soft capsules were all> 0.97. Conclusion: The method has good precision, repeatability and stability, and can be used for the comprehensive evaluation of Yinqiao Jiedu soft capsule quality.