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目的探讨TCF7L2的基因单核苷酸多态性(SNP)rs7903146与肥胖儿童青少年代谢异常的相关性。方法701例3～18岁儿童青少年,根据体质指数(BMI)分为正常、肥胖、超重组,测定三酰甘油(TG)、总胆固醇(TCH)、空腹血糖(FPG)、空腹胰岛素(Fins),计算胰岛素抵抗指数(HOMA-IR)和定量胰岛素敏感指数(QUICKI),并研究TCF7L2基因SNP rs7903146在各组间的分布及不同基因型之间代谢指标的差异。结果正常组与肥胖/超重组间的等位基因频率差异无统计学意义(P=1.000),单核苷酸多态性与各项代谢指标之间无显著相关(P>0.05),不同基因型之间的空腹血糖异常、高脂血症、高胰岛素血症发生率差异无统计学意义(P>0.05),CC基因型HOMA-IR明显高于CT基因型(P=0.048),两者之间差异有统计学意义。结论 TCF7L2基因SNP rs7903146与肥胖儿童青少年的糖、脂代谢异常无明显相关,其基因型与胰岛素抵抗及胰岛素敏感性可能有关。
Objective To investigate the association between TCF7L2 gene SNP rs7903146 and metabolic abnormalities in obese children and adolescents. Methods A total of 701 adolescents aged 3 to 18 years old were divided into normal, obese and overweight groups according to body mass index (BMI). The triglyceride (TG), total cholesterol (TCH), fasting blood glucose (FPG), fasting insulin (Fins) (HOMA-IR) and quantitative insulin sensitivity index (QUICKI) were calculated. The distribution of SNP rs7903146 in TCF7L2 gene and the differences in the metabolic indices between different genotypes were also studied. Results There was no significant difference in allele frequency between normal group and obesity / overweight group (P = 1.000). There was no significant correlation between single nucleotide polymorphisms and various metabolic indexes (P> 0.05) (P> 0.05). The HOMA-IR of CC genotype was significantly higher than that of CT genotype (P = 0.048), both of them had no significant difference in fasting blood glucose, hyperlipidemia and hyperinsulinemia The difference was statistically significant. Conclusion TCF7L2 gene SNP rs7903146 has no significant correlation with abnormal glucose and lipid metabolism in obese children and adolescents, and its genotype may be related to insulin resistance and insulin sensitivity.