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目的了解抗庚型肝炎病毒抗体（抗－ＨＧＶ）在各型病毒性肝炎患者中的检出情况及临床意义。方法对１９０例不同病原的病毒性肝炎患者进行抗－ＨＧＶ（ＥＬＩＳＡ）检测，对其中抗－ＨＧＶ阳性者进行ＨＧＶ－ＲＮＡ（ＲＴＰＣＲ）检测。结果①在各型病毒性肝炎患者中总的抗－ＨＧＶ阳性率为１２１％（２３／１９０）。②ＨＣＶ感染者中抗－ＨＧＶ的阳性率（２６９％）最高，其后依次为ＨＥＶ（１８２％），ＨＢＶ（１１２％），ＨＤＶ（８３％）。③２３例抗－ＨＧＶ阳性的患者中仅有５例（２１７％）ＨＧＶ－ＲＮＡ同时检测阳性。④抗－ＨＧＶ阳性组与抗－ＨＧＶ阴性组比较，两组肝功能指标无统计学差异（Ｐ＞００５）。结论①抗－ＨＧＶ阳性并不一定代表ＨＧＶ病毒复制或现症感染。②ＨＧＶ致病性可能较弱。③ＨＧＶ可能通过多途径传播。
Objective To understand the detection and clinical significance of anti-hepatitis G virus antibody (anti-HGV) in various types of viral hepatitis. Methods Totally 190 patients with viral hepatitis with different pathogenicity were tested for anti-HGV (ELISA), and HGV-RNA (RTPCR) was detected in anti-HGV positive patients. Results ① The positive rate of anti-HGV in all types of viral hepatitis was 12.1% (23/190). ② The positive rate of anti-HGV in HCV infection was the highest (269%), followed by HEV (182%), HBV (112%) and HDV (83%). ③ Only 23 of the 23 anti-HGV positive patients (21.7%) were positive for HGV-RNA at the same time. ④ The anti-HGV positive group and anti-HGV negative group, no significant difference between the two groups of liver function indicators (P> 0 05). Conclusion ① The positive anti-GHV does not necessarily represent the replication of HGV virus or the infection of the disease. ②HVV pathogenicity may be weak. HGV may be transmitted through multiple channels.