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瘦素是肥胖基因(ob基因)的编码产物,通过与其受体结合在体内发挥多种生物学作用,调节摄食、能量代谢、生殖、造血、免疫等生理功能,参与炎性反应、损伤修复等病理生理过程。肝纤维化是多种原因所致慢性肝损伤的修复反应,是各种慢性肝病共同的病理基础。研究发现瘦素与肝纤维化的发生发展有一定的关系,本文就此作一综述。
Leptin is a coding product of ob gene (ob gene), which binds to its receptors and plays a variety of biological roles in the body and regulates physiological functions such as food intake, energy metabolism, reproduction, hematopoiesis, and immunity, and is involved in inflammatory reactions, injury repair and the like Pathophysiological process. Liver fibrosis is a repair reaction of chronic liver injury caused by a variety of reasons and is the common pathological basis of various chronic liver diseases. The study found that leptin and liver fibrosis have a certain relationship between the occurrence and development of this article to make a review.