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目的：探讨巨细胞病毒（ＣＭＶ）的先天性感染对新生儿胎龄、体重的影响。方法：对１８６例早产适于胎龄儿、１４２例小于胎龄儿（ＳＧＡ）和９５例足月儿与其母配对，用酶联免疫吸附法和免疫组织化学法分别检测抗 ＣＭＶ特异性 ＩｇＭ抗体及巨细胞病毒抗原（ ＣＭＶＡｇ）。结果： ＣＭＶ先天性感染率 ＳＧＡ组为３１．７％（４５／１４２），明显高于早产适于胎龄儿组的８．１％（１５／１８６）和足月儿对照组的５．２％（５／９５）。结论：小于胎龄儿的产生可能与 ＣＭＶ的先天性感染有关。并且提示胎龄愈小，出生体重愈低，先天性感染率愈高。
Objective: To investigate the effect of congenital infection of cytomegalovirus (CMV) on the gestational age and body weight of neonates. Methods: 186 pregnant women with preterm birth, 142 with small gestational age (SGA) and 95 full-term infants were matched with their mothers. The anti-CMV specific IgM antibodies were detected by enzyme-linked immunosorbent assay and immunohistochemistry respectively And cytomegalovirus antigen (CMVAg). Results: The congenital infection rate of CMV was 31.7% (45/142) in SGA group, which was significantly higher than 8.1% (15/186) in gestational age preterm group and 5.2 in term control group % (5/95). CONCLUSIONS: The development of children younger than gestational age may be related to the congenital infection of CMV. And that gestational age is smaller, lower birth weight, the higher the rate of congenital infection.