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Dear Editors,rnThe coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, broke out in early December 2019 has escalated into a global pandemic (Lai et al.2020).Till the May 20th 2020, more than 4,700,000 people were infected and the number is still increasing especially in Europe,North America and Asia (https://covid19.who.int/).And there is an urgent need to understand the biology of SARS-CoV-2.Here we report the isolation and characterization of seven isolates of SARS-CoV-2 from seven patients.All these isolates were adapted to grow in Vero cells, and showed significant different replication characteristics.