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叉头转录因子O亚型(forkhead box O,FoxO)3a是FoxO家族一员,具有抑癌基因的作用,调控多种肿瘤的发生发展,包括乳腺癌、前列腺癌、白血病、胶质母细胞瘤等。FoxO3a作为磷脂酰肌醇3-激酶/蛋白激酶B(phosphatidylinositol 3-kinase/protein kinase B,PI3K/Akt)信号通路的重要靶分子,主要通过AKT磷酸化与去磷酸化起作用,调节其活性以及下游信号分子如细胞死亡调解因子、Fas配体和细胞周期蛋白依赖性激酶等转录作用,诱导肿瘤细胞凋亡。药物调控FoxO3a的活性和分布有望成为癌症治疗的新思路。
Forkhead box O (FoxO) 3a, a member of FoxO family, has the function of tumor suppressor gene and regulates the development of various tumors including breast cancer, prostate cancer, leukemia, glioblastoma Wait. As an important target of phosphatidylinositol 3-kinase / protein kinase B (PI3K / Akt) signaling pathway, FoxO3a plays a key role in phosphorylation and dephosphorylation of AKT, regulating its activity and Downstream signaling molecules such as cell death mediators, Fas ligand and cyclin-dependent kinases induce apoptosis in tumor cells. Drug regulation FoxO3a activity and distribution is expected to become a new idea of cancer treatment.