论文部分内容阅读
目的 观察低分子肝素对系膜增殖性肾小球肾炎的治疗作用。方法 用抗鼠类胸腺细胞表面的糖蛋白抗原 (Thy1 1)单克隆抗体 1 2 2 3诱导Wistar大鼠系膜增殖性肾小球肾炎 ,用低分子肝素或低分子肝素加地塞米松治疗 ,通过免疫组化、透射电镜和常规病理染色 ,观察肾小球内细胞总数、增殖细胞核抗原 (PCNA)、肾小球系膜基质以及蛋白尿排泄动力学改变。结果 低分子肝素可降低肾小球内细胞总数和减少肾小球内增殖细胞的数量 ,抑制系膜基质的增生和减轻尿蛋白的排泄。结论 低分子肝素可治疗系膜增殖性肾小球肾炎
Objective To observe the therapeutic effect of low molecular weight heparin on mesangial proliferative glomerulonephritis. Methods Wistar rat mesangial proliferative glomerulonephritis was induced by monoclonal antibody against glycoprotein antigen (Thy1 1) on the surface of murine thymocytes and treated with low molecular weight heparin or low molecular weight heparin plus dexamethasone Immunohistochemistry, transmission electron microscopy and routine pathological staining were used to observe the changes of total glomerular cells, proliferating cell nuclear antigen (PCNA), glomerular mesangial matrix and proteinuria excretion dynamics. Results Low molecular weight heparin can reduce the total number of glomerular cells and reduce the number of glomerular proliferating cells, inhibit mesangial matrix proliferation and reduce urinary protein excretion. Conclusion Low molecular weight heparin can treat mesangial proliferative glomerulonephritis