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测定了克山病病区粮喂养大鼠心肌线粒体α－磷酸甘油脱氢酶（ａ－ＧＰＤ）活性，并观察了硒和维生素Ｅ对该酶的影响。结果表明，病区粮组大鼠心肌线粒体α－ＧＰＤ活力明显低于非病区粮组和常规．食组，并在补０．１μｇ／ｇ＋８００μｇ／ｇＶＥ后，α－ＧＰＤ活性升高与病区粮组比较有显著差异、本实验结果提示：１、饲克山病病区粮大鼠心肌线粒体α－ＧＰＤ活力的降低，此时的心肌可能处于甲状腺激素功能低下状态．２、硒（０．１μｇ／ｇ）＋维生素Ｅ（８００μｇ／ｇ）的补充可以升高该酶活性，改善甲状腺激素功能不足状态。
The a-GPD activity of myocardial mitochondria in food-fed rats of Keshan disease was measured and the effect of selenium and vitamin E on this enzyme was observed. The results showed that the mitochondrial α-GPD activity in myocardium of Wistar rats was significantly lower than that of non-wed rats. The results showed that: 1, myocardial Kawasaki disease rats myocardial mitochondrial α (α-GPD) activity in rats fed with dietary 0.1g / g + 800μg / gVE, - GPD decreased vitality, this time the myocardium may be in thyroid hormone dysfunction state. Supplementation of selenium (0.1μg / g) + vitamin E (800μg / g) can increase the enzyme activity and improve thyroid hormone deficiency.