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目的观察肾炎康复片联合还原型谷胱甘肽治疗糖尿病肾病的疗效。方法选择2012年5月—2015年5月来天津市第一中心医院就诊的糖尿病肾病患者100例,随机分为对照组和治疗组,每组各50例。对照组患者静脉滴注注射用还原型谷胱甘肽,1.8 mg/次,1次/d;治疗组患者在对照组的基础上口服肾炎康复片,5片/次,3次/d,两组均连续治疗15 d。比较两组治疗前后的临床疗效,血糖(FPG)和餐后2 h血糖(2 h PG)、收缩压(SBP)和舒张压(DBP)、总胆固醇(TC)和三酰甘油(TG)以及肾功能指标血肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白、白蛋白和N-乙酰β-D-葡萄糖苷酶(NAG)的变化。结果治疗后,对照组和治疗组的总有效率分别为84.00%、96.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组的血糖、血压、血脂均比治疗前显著改善,同组治疗前后差异有统计学意义(P<0.01);且治疗组患者的SBP和TC改善的更为明显,两组比较差异有统计学意义(P<0.05)。对照组的Scr、BUN、NAG水平均明显下降,治疗组的Scr、BUN、24 h尿蛋白、白蛋白、NAG水平均明显下降,同组治疗前后差异有统计学意义(P<0.01);且治疗组的肾功能指标改善的更为明显,两组比较差异有统计学意义(P<0.01)。结论肾炎康复片联合还原型谷胱甘肽治疗糖尿病肾病具有良好的疗效,具有一定的临床推广应用价值。
Objective To observe the effect of nephritis and kangsu tablets combined with reduced glutathione on diabetic nephropathy. Methods One hundred patients with diabetic nephropathy who visited the First Central Hospital of Tianjin from May 2012 to May 2015 were randomly divided into control group and treatment group, 50 cases in each group. Control group patients intravenous injection of reduced glutathione, 1.8 mg / time, 1 / d; treatment group patients in the control group based on oral nephritis rehabilitation tablets, 5 tablets / time, 3 times / d, two Group were treated for 15 days. The clinical curative effect, blood glucose (FPG) and postprandial 2h blood glucose (2h PG), systolic blood pressure (SBP) and diastolic blood pressure (DBP), total cholesterol (TC) and triglyceride (TG) Changes of serum creatinine (Scr), blood urea nitrogen (BUN), 24 h urinary protein, albumin and N-acetyl β-D-glucosidase (NAG) Results After treatment, the total effective rates of the control group and the treatment group were 84.00% and 96.00%, respectively, with significant difference between the two groups (P <0.05). After treatment, blood glucose, blood pressure and blood lipid of the two groups were significantly improved than before treatment, the difference was statistically significant (P <0.01) before and after treatment in the same group; SBP and TC in the treatment group improved more obviously The difference was statistically significant (P <0.05). The levels of Scr, BUN and NAG in the control group were significantly decreased. The levels of Scr, BUN, 24 h urinary protein, albumin and NAG in the treatment group were significantly decreased, the difference was statistically significant (P <0.01) before and after treatment; The renal function of the treatment group improved more obviously, the difference between the two groups was statistically significant (P <0.01). Conclusion Shenyinkang tablets combined with reduced glutathione treatment of diabetic nephropathy has a good effect, with some clinical application value.